Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome

X-linked severe combined immunodeficiency (X-SCID) is caused by mutations of IL2RG, the gene encoding the interleukin common gamma chain (IL-2Rγ or γc) of cytokine receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Hypomorphic mutations of IL2RG may cause combined immunodeficienci...

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Bibliographic Details
Main Authors: Brahim Belaid, Lydia Lamara Mahammed, Aida Mohand Oussaid, Melanie Migaud, Yasmine Khadri, Jean Laurent Casanova, Anne Puel, Nafissa Ben Halla, Reda Djidjik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
Interleukin-2 receptor gamma
combined immunodeficiency
hypomorphic mutations
hyper-IgE
inborn error of immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.696350/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.696350/full

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