Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice.

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice.

We have used homozygous albumin enhancer/promoter-driven urokinase-type plasminogen activator/severe combined immunodeficient (uPA/SCID) mice as hosts for chimeric mice with humanized livers. However, uPA/SCID mice show four disadvantages: the human hepatocytes (h-heps) replacement index in mouse li...

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Bibliographic Details
Main Authors: Chise Tateno, Yosuke Kawase, Yoshimi Tobita, Satoko Hamamura, Hiroki Ohshita, Hiroshi Yokomichi, Harumi Sanada, Masakazu Kakuni, Akira Shiota, Yuha Kojima, Yuji Ishida, Hiroshi Shitara, Naoko A Wada, Hiromi Tateishi, Masayuki Sudoh, Shin-Ichiro Nagatsuka, Kou-Ichi Jishage, Michinori Kohara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4633119?pdf=render

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http://europepmc.org/articles/PMC4633119?pdf=render

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