Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions
This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were as...
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doaj-075a8fddd5664c2da47cad54861633fe2020-11-25T02:23:07ZengMDPI AGNutrients2072-66432019-11-011111269310.3390/nu11112693nu11112693Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological FunctionsAmaia Iriondo-DeHond0Maria Belen Rios1Teresa Herrera2Antonio Rodriguez-Bertos3Fernando Nuñez4Manuel Ignacio San Andres5Sebastian Sanchez-Fortun6Maria Dolores del Castillo7Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Calle Nicolas Cabrera 9, 28049 Madrid, SpainInstituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Calle Nicolas Cabrera 9, 28049 Madrid, SpainInstituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Calle Nicolas Cabrera 9, 28049 Madrid, SpainDepartment of Internal Medicine and Animal Surgery, School of Veterinary Sciences, Health Surveillance Center (VISAVET), Complutense University, Puerta de Hierro Ave, 28040 Madrid, SpainCentro de Biología Molecular Severo Ochoa (CBMSO, CSIC-UAM), Calle Nicolás Cabrera, 1, 28049 Madrid, SpainFacultad de Veterinaria, Universidad Complutense de Madrid, Av. Puerta de Hierro, s/n, 28040 Madrid, SpainFacultad de Veterinaria, Universidad Complutense de Madrid, Av. Puerta de Hierro, s/n, 28040 Madrid, SpainInstituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), Calle Nicolas Cabrera 9, 28049 Madrid, SpainThis study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, amino acids, fat, fatty acids, fiber, simple sugars and micronutrients were analyzed. For the first time, toxicological and physiological effects were evaluated in vivo by a repeated-dose study in healthy Wistar rats. Hormone secretion, antioxidant (enzymatic and no-enzymatic) and anti-inflammatory biomarkers, and dietary fiber fermentability of CSE (analysis of SCFAs in feces) were studied in biological samples. This unique research confirms the feasibility of CSE as a human dietary supplement with several nutrition claims: “source of proteins (16%), potassium, magnesium, calcium and vitamin C, low in fat (0.44%) and high in fiber (22%)”. This is the first report demonstrating that its oral administration (1 g/kg) for 28 days is innocuous. Hormone secretion, antioxidant or anti-inflammatory biomarkers were not affected in heathy animals. Total SCFAs derived from CSE fiber fermentation were significantly higher (<i>p</i> < 0.05) in male treated rats compared to male control rats. All the new information pinpoints CSE as a natural, sustainable and safe food ingredient containing fermentable fiber able to produce SCFAs with beneficial effects on gut microbiota.https://www.mdpi.com/2072-6643/11/11/2693antioxidantcoffee silverskinfood safetynovel foodnutritionshort-chain fatty acids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amaia Iriondo-DeHond Maria Belen Rios Teresa Herrera Antonio Rodriguez-Bertos Fernando Nuñez Manuel Ignacio San Andres Sebastian Sanchez-Fortun Maria Dolores del Castillo |
spellingShingle |
Amaia Iriondo-DeHond Maria Belen Rios Teresa Herrera Antonio Rodriguez-Bertos Fernando Nuñez Manuel Ignacio San Andres Sebastian Sanchez-Fortun Maria Dolores del Castillo Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions Nutrients antioxidant coffee silverskin food safety novel food nutrition short-chain fatty acids |
author_facet |
Amaia Iriondo-DeHond Maria Belen Rios Teresa Herrera Antonio Rodriguez-Bertos Fernando Nuñez Manuel Ignacio San Andres Sebastian Sanchez-Fortun Maria Dolores del Castillo |
author_sort |
Amaia Iriondo-DeHond |
title |
Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions |
title_short |
Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions |
title_full |
Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions |
title_fullStr |
Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions |
title_full_unstemmed |
Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions |
title_sort |
coffee silverskin extract: nutritional value, safety and effect on key biological functions |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-11-01 |
description |
This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, amino acids, fat, fatty acids, fiber, simple sugars and micronutrients were analyzed. For the first time, toxicological and physiological effects were evaluated in vivo by a repeated-dose study in healthy Wistar rats. Hormone secretion, antioxidant (enzymatic and no-enzymatic) and anti-inflammatory biomarkers, and dietary fiber fermentability of CSE (analysis of SCFAs in feces) were studied in biological samples. This unique research confirms the feasibility of CSE as a human dietary supplement with several nutrition claims: “source of proteins (16%), potassium, magnesium, calcium and vitamin C, low in fat (0.44%) and high in fiber (22%)”. This is the first report demonstrating that its oral administration (1 g/kg) for 28 days is innocuous. Hormone secretion, antioxidant or anti-inflammatory biomarkers were not affected in heathy animals. Total SCFAs derived from CSE fiber fermentation were significantly higher (<i>p</i> < 0.05) in male treated rats compared to male control rats. All the new information pinpoints CSE as a natural, sustainable and safe food ingredient containing fermentable fiber able to produce SCFAs with beneficial effects on gut microbiota. |
topic |
antioxidant coffee silverskin food safety novel food nutrition short-chain fatty acids |
url |
https://www.mdpi.com/2072-6643/11/11/2693 |
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