Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns

Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns

Background: Besides its well-known functions in hemostasis, thrombin plays a role in various non-hemostatic biological and pathophysiologic processes. We examined the potential of thrombin to promote premature atrial endothelial cells (ECs) senescence. Methods and Results: Primary ECs were isolated...

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Bibliographic Details
Main Authors: Hira Hasan, Sin-Hee Park, Cyril Auger, Eugenia Belcastro, Kensuke Matsushita, Benjamin Marchandot, Hyun-Ho Lee, Abdul Wahid Qureshi, Gilles Kauffenstein, Patrick Ohlmann, Valérie B Schini-Kerth, Laurence Jesel, Olivier Morel
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Journal of Clinical Medicine
Subjects:
senescence
thrombin
atrial fibrillation
endothelium
angiotensin ii
remodeling
Online Access:https://www.mdpi.com/2077-0383/8/10/1570

Internet

https://www.mdpi.com/2077-0383/8/10/1570

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