Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates.

Recombinant vesicular stomatitis virus vaccine vectors expressing filovirus glycoproteins lack neurovirulence in nonhuman primates.

The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (rVSV) that expresses an individual filovirus...

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Bibliographic Details
Main Authors: Chad E Mire, Andrew D Miller, Angela Carville, Susan V Westmoreland, Joan B Geisbert, Keith G Mansfield, Heinz Feldmann, Lisa E Hensley, Thomas W Geisbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3308941?pdf=render

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http://europepmc.org/articles/PMC3308941?pdf=render

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