Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity

Multifunctional Isosteric Pyridine Analogs-Based 2-Aminothiazole: Design, Synthesis, and Potential Phosphodiesterase-5 Inhibitory Activity

The elaboration of new small molecules that target phosphodiesterase enzymes (PDEs), especially those of type 5 (PDE5), is an interesting and emerging topic nowadays. A new series of heterocycle-based aminothiazoles were designed and synthesized from the key intermediate, 3-oxo-<i>N</i>-...

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Bibliographic Details
Main Authors: Abdel Haleem M. Hussein, Ahmed A. Khames, Abu-Bakr A. El-Adasy, Ahmed A. Atalla, Mohamed Abdel-Rady, Mohamed I. A. Hassan, Mahrous A. Abou-Salim, Yaseen A. M. M. Elshaier, Assem Barakat
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
2-aminothiazoles
phosphodiesterase 5
sildenafil
erectile dysfunction
docking
OpenEye
Online Access:https://www.mdpi.com/1420-3049/26/4/902

Internet

https://www.mdpi.com/1420-3049/26/4/902

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