Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury

Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury

Purpose: The etiopathogenesis of drug-induced liver injury (DILI) is still far from being elucidated. This study aims to the study of genetic variations in DILI, related to the drug target, and specifically in the genes coding for the cyclooxygenase enzymes.Methods: By using Next-generation Sequenci...

Full description

Bibliographic Details
Main Authors: María Isabel Lucena, Elena García-Martín, Ann K. Daly, Miguel Blanca, Raúl J. Andrade, José A. G. Agúndez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Genetics
Subjects:
PTGS1
PTGS2
next generation sequencing
drug-induced liver injury
COX1
COX2
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00134/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00134/full

Similar Items