Preliminary Evidence for Aortopathy and an X-Linked Parent-of-Origin Effect on Aortic Valve Malformation in a Mouse Model of Turner Syndrome

Preliminary Evidence for Aortopathy and an X-Linked Parent-of-Origin Effect on Aortic Valve Malformation in a Mouse Model of Turner Syndrome

Turner syndrome (TS), most frequently caused by X-monosomy (45,X), is characterized in part by cardiovascular abnormalities, including aortopathy and bicuspid aortic valve (BAV). There is a need for animal models that recapitulate the cardiovascular manifestations of TS. Extracellular matrix (ECM) o...

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Bibliographic Details
Main Authors: Robert B. Hinton, Amy M. Opoka, Obah A. Ojarikre, Lawrence S. Wilkinson, William Davies
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
cardiovascular malformation
valves
heritability
disease models
genomic imprinting
Xlr3b
FAM9B
39,XO
Online Access:http://www.mdpi.com/2308-3425/2/3/190

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http://www.mdpi.com/2308-3425/2/3/190

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