Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.

Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis.

BACKGROUND: Sphingosine-1-phosphate (S1P) regulates the egress of T cells from lymphoid organs; levels of S1P in the tissues are controlled by S1P lyase (Sgpl1). Hence, Sgpl1 offers a target to block T cell-dependent inflammatory processes. However, the involvement of Sgpl1 in models of disease has...

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Main Authors: Andreas Billich, Thomas Baumruker, Christian Beerli, Marc Bigaud, Christian Bruns, Thomas Calzascia, Andrea Isken, Bernd Kinzel, Erika Loetscher, Barbara Metzler, Matthias Mueller, Barbara Nuesslein-Hildesheim, Bernadette Kleylein-Sohn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3609791?pdf=render

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http://europepmc.org/articles/PMC3609791?pdf=render

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