Cannabidiol Acts at 5-HT1A Receptors in the Human Brain: Relevance for Treating Temporal Lobe Epilepsy

Cannabidiol Acts at 5-HT1A Receptors in the Human Brain: Relevance for Treating Temporal Lobe Epilepsy

Experimental evidence indicates that cannabidiol (CBD) induces anxiolytic and antiepileptic effects through the activation of 5-HT1A receptors. These receptors are coupled to Gi/o proteins and induce inhibitory effects. At present, the interaction of CBD with 5-HT1A receptors in the human brain is u...

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Bibliographic Details
Main Authors: Christopher Martínez-Aguirre, Francia Carmona-Cruz, Ana Luisa Velasco, Francisco Velasco, Gustavo Aguado-Carrillo, Manola Cuéllar-Herrera, Luisa Rocha
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
serotonin
5-HT1A receptor
hippocampus
mesial temporal lobe epilepsy
drug-resistant epilepsy
cannabidiol
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2020.611278/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2020.611278/full

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