Two in One: Use of Divalent Manganese Ions as Both Cross-Linking and MRI Contrast Agent for Intrathecal Injection of Hydrogel-Embedded Stem Cells

Two in One: Use of Divalent Manganese Ions as Both Cross-Linking and MRI Contrast Agent for Intrathecal Injection of Hydrogel-Embedded Stem Cells

Cell therapy is a promising tool for treating central nervous system (CNS) disorders; though, the translational efforts are plagued by ineffective delivery methods. Due to the large contact surface with CNS and relatively easy access, the intrathecal route of administration is attractive in extensiv...

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Bibliographic Details
Main Authors: Lukasz Kalkowski, Dominika Golubczyk, Joanna Kwiatkowska, Piotr Holak, Kamila Milewska, Miroslaw Janowski, Joaquim Miguel Oliveira, Piotr Walczak, Izabela Malysz-Cymborska
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
hydrogel
manganese
contrast agent
biomaterial
intrathecal
large animals
Online Access:https://www.mdpi.com/1999-4923/13/7/1076

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https://www.mdpi.com/1999-4923/13/7/1076

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