Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

The PKN (protein kinase N) family of Ser/Thr protein kinases regulates a diverse set of cellular functions, such as cell migration and cytoskeletal organization. Inhibition of tumour PKN activity has been explored as an oncology therapeutic approach, with a PKN3-targeted RNAi (RNA interference)-der...

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Bibliographic Details
Main Authors: Matthew D. Falk, Wei Liu, Ben Bolaños, Keziban Unsal‑Kacmaz, Anke Klippel, Stephan Grant, Alexei Brooun, Sergei Timofeevski
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-03-01
Series:Bioscience Reports
Subjects:
AGC kinase
cancer
kinase inhibitor
kinetic mechanism
lipid
protein kinase N (PKN)
Online Access:http://www.bioscirep.org/bsr/034/e097/bsr034e097.htm

Internet

http://www.bioscirep.org/bsr/034/e097/bsr034e097.htm

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