Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

Abstract Background Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to sunitinib, the C(5)-Br derivative of 2-pyrrolidone-fused (2-oxoindolin-3...

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Bibliographic Details
Main Authors: Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang, An-Rong Lee
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Chemistry Central Journal
Subjects:
Multi-target kinase inhibitor
VEGFR-2 inhibitor
PDGFRβ inhibitor angiogenesis
(2-oxoindolin-3-ylidene)methylpyrrole
Hydrogen-bond-donating
Online Access:http://link.springer.com/article/10.1186/s13065-017-0301-5

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http://link.springer.com/article/10.1186/s13065-017-0301-5

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