Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

Abstract X-ray irradiation of high Z elements causes photoelectric effects that include the release of Auger electrons that can induce localized DNA breaks. We have previously established a tumor spheroid-based assay that used gadolinium containing mesoporous silica nanoparticles and synchrotron-gen...

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Bibliographic Details
Main Authors: Yuya Higashi, Kotaro Matsumoto, Hiroyuki Saitoh, Ayumi Shiro, Yue Ma, Mathilde Laird, Shanmugavel Chinnathambi, Albane Birault, Tan Le Hoang Doan, Ryo Yasuda, Toshiki Tajima, Tetsuya Kawachi, Fuyuhiko Tamanoi
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93429-9

Internet

https://doi.org/10.1038/s41598-021-93429-9

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