Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing

Engineering T cells with hypoxia-inducible chimeric antigen receptor (HiCAR) for selective tumor killing

Abstract Chimeric antigen receptor-modified T cells (CAR-T cells) have shown good effects in the treatment of hematologic cancers; however, they may cause on-target off-tumor toxicity because of minimal expression of tumor-associated antigens (TAAs) on normal tissues, particularly in the context of...

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Bibliographic Details
Main Authors: Qibin Liao, Huan He, Yunyu Mao, Xiangqing Ding, Xiaoyan Zhang, Jianqing Xu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Biomarker Research
Subjects:
On-target off-tumor
Hypoxia
Hypoxia-inducible CAR
Hypoxia response element
Online Access:http://link.springer.com/article/10.1186/s40364-020-00238-9

Internet

http://link.springer.com/article/10.1186/s40364-020-00238-9

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