A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line

A Chimeric NaV1.8 Channel Expression System Based on HEK293T Cell Line

Among the nine voltage-gated sodium channel (NaV) subtypes, NaV1.8 is an attractive therapeutic target for pain. The heterologous expression of recombinant NaV1.8 currents is of particular importance for its electrophysiological and pharmacological studies. However, NaV1.8 expresses no or low-level...

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Bibliographic Details
Main Authors: Xi Zhou, Yunxiao Zhang, Dongfang Tang, Songping Liang, Ping Chen, Cheng Tang, Zhonghua Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
NaV1.8
functional expression
HEK293T
pharmacology
APETx-2
MrVIB
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00337/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00337/full

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