VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway

VDR Activation Reduces Proteinuria and High-Glucose-Induced Injury of Kidneys and Podocytes by Regulating Wnt Signaling Pathway

Background: Diabetic nephropathy (DN) is a major cause of end-stage renal disease and proteinuria is one of the most prominent clinical manifestations. The expression of Vitamin D receptor (VDR) in patients with chronic kidney diseases was decreased, while VDR agonists could partially alleviate the...

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Bibliographic Details
Main Authors: Jia Guo, Congqun Lu, Fangxing Zhang, Haixia Yu, Mengwen Zhou, Meixia He, Chunyan Wang, Zhanzheng Zhao, Zhangsuo Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Diabetic nephropathy
Proteinuria
Podocytes
Vitamin D receptor
Paricalcitol
Wnt signaling pathway
Online Access:http://www.karger.com/Article/FullText/480315

Internet

http://www.karger.com/Article/FullText/480315

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