Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3<i>H</i>-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3<i>H</i>-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

About 70 million people suffer from epilepsy—a chronic neurodegenerative disease. In most cases, the cause of the disease is unknown, but epilepsy can also develop as the result of a stroke, trauma to the brain, or the use of psychotropic substances. The treatment of epilepsy is mainly based on the...

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Bibliographic Details
Main Authors: Anna Makuch-Kocka, Marta Andres-Mach, Mirosław Zagaja, Anna Śmiech, Magdalena Pizoń, Jolanta Flieger, Judyta Cielecka-Piontek, Tomasz Plech
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
epilepsy
hepatotoxicity
nephrotoxicity
1,2,4-triazole-3-thione derivatives
CYP450 enzymes
antiepileptic drugs
Online Access:https://www.mdpi.com/1422-0067/22/7/3358

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https://www.mdpi.com/1422-0067/22/7/3358

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