Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes

Zika virus infection of pregnant women is associated with congenital neurological disorders. Here, Vermillionet al. develop an immunocompetent mouse model for identification of factors at the maternal-fetal interface that contribute to adverse perinatal outcomes.

Bibliographic Details
Main Authors: Meghan S. Vermillion, Jun Lei, Yahya Shabi, Victoria K. Baxter, Nathan P. Crilly, Michael McLane, Diane E. Griffin, Andrew Pekosz, Sabra L. Klein, Irina Burd
Format: Article
Language:English
Published: Nature Publishing Group 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14575
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spelling doaj-07a4afde47914fd08d15bf3ae8f56bc72021-05-11T07:17:10ZengNature Publishing GroupNature Communications2041-17232017-02-018111410.1038/ncomms14575Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomesMeghan S. Vermillion0Jun Lei1Yahya Shabi2Victoria K. Baxter3Nathan P. Crilly4Michael McLane5Diane E. Griffin6Andrew Pekosz7Sabra L. Klein8Irina Burd9W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthDepartment of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University School of MedicineDepartment of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University School of MedicineW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthDepartment of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University School of MedicineW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public HealthDepartment of Gynecology and Obstetrics, Integrated Research Center for Fetal Medicine, Johns Hopkins University School of MedicineZika virus infection of pregnant women is associated with congenital neurological disorders. Here, Vermillionet al. develop an immunocompetent mouse model for identification of factors at the maternal-fetal interface that contribute to adverse perinatal outcomes.https://doi.org/10.1038/ncomms14575
collection DOAJ
language English
format Article
sources DOAJ
author Meghan S. Vermillion
Jun Lei
Yahya Shabi
Victoria K. Baxter
Nathan P. Crilly
Michael McLane
Diane E. Griffin
Andrew Pekosz
Sabra L. Klein
Irina Burd
spellingShingle Meghan S. Vermillion
Jun Lei
Yahya Shabi
Victoria K. Baxter
Nathan P. Crilly
Michael McLane
Diane E. Griffin
Andrew Pekosz
Sabra L. Klein
Irina Burd
Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes
Nature Communications
author_facet Meghan S. Vermillion
Jun Lei
Yahya Shabi
Victoria K. Baxter
Nathan P. Crilly
Michael McLane
Diane E. Griffin
Andrew Pekosz
Sabra L. Klein
Irina Burd
author_sort Meghan S. Vermillion
title Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes
title_short Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes
title_full Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes
title_fullStr Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes
title_full_unstemmed Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes
title_sort intrauterine zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-02-01
description Zika virus infection of pregnant women is associated with congenital neurological disorders. Here, Vermillionet al. develop an immunocompetent mouse model for identification of factors at the maternal-fetal interface that contribute to adverse perinatal outcomes.
url https://doi.org/10.1038/ncomms14575
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