Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes

Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes

A library of 21 novel chiral 1,2,3-triazole-based 2-azabicycloalkane conjugates was designed and synthesized using the copper(I)-catalyzed click reaction. The obtained hybrids were assessed for their antiproliferative potency against three selected human cancer cell lines: Hs294T (melanoma), MIA PaC...

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Bibliographic Details
Main Authors: Franz Steppeler, Dagmara Kłopotowska, Joanna Wietrzyk, Elżbieta Wojaczyńska
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Materials
Subjects:
2-azabicycloalkanes
antiproliferative activity
cancer
CuAAC
triazoles
Online Access:https://www.mdpi.com/1996-1944/14/8/2039

Internet

https://www.mdpi.com/1996-1944/14/8/2039

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