The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Abstract Background Mutations in PINK1 and PARKIN are the most common causes of recessive early-onset Parkinson’s disease (EOPD). Together, the mitochondrial ubiquitin (Ub) kinase PINK1 and the cytosolic E3 Ub ligase PARKIN direct a complex regulated, sequential mitochondrial quality control. Thereb...

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Bibliographic Details
Main Authors: Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek, Wolfdieter Springer
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
PINK1
PARKIN
Ubiquitin
Mitophagy
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13024-017-0174-z

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http://link.springer.com/article/10.1186/s13024-017-0174-z

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