Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy
Intratumoural spatial heterogeneity is crucial to enhance therapeutic resistance in glioblastoma. Here, the authors show a paracrine signaling mechanism where glioblastoma-initiating cells located in the tumour edge elevate their malignancy by interaction with core-located tumour cells.
Bibliographic Details
| Main Authors: |
Soniya Bastola,
Marat S. Pavlyukov,
Daisuke Yamashita,
Sadashib Ghosh,
Heejin Cho,
Noritaka Kagaya,
Zhuo Zhang,
Mutsuko Minata,
Yeri Lee,
Hirokazu Sadahiro,
Shinobu Yamaguchi,
Svetlana Komarova,
Eddy Yang,
James Markert,
Louis B. Nabors,
Krishna Bhat,
James Lee,
Qin Chen,
David K. Crossman,
Kazuo Shin-Ya,
Do-Hyun Nam,
Ichiro Nakano |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-18189-y
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