Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties

by Keisuke Iida, Masayuki Tera, Takatsugu Hirokawa, Kazuo Shin-ya, Kazuo Nagasawa
Published 2010-01-01

Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete.

by Philipp Zeyhle, Judith S Bauer, Jörn Kalinowski, Kazuo Shin-ya, Harald Gross, Lutz Heide
Published 2014-01-01

G-Quadruplexes as Potential Therapeutic Targets for Embryonal Tumors

by Michael Grotzer, Kazuo Shin-ya, Martin Baumgartner, Tarek Shalaby, Giulio Fiaschetti, Kazuo Nagasawa
Published 2013-10-01

Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.

by Sakae Saito, Aki Furuno, Junko Sakurai, Hae-Ryong Park, Kazuo Shin-ya, Akihiro Tomida
Published 2012-01-01

Cation Involvement in Telomestatin Binding to G-Quadruplex DNA

by Frédéric Rosu, Valérie Gabelica, Nicolas Smargiasso, Gabriel Mazzucchelli, Kazuo Shin-Ya, Edwin De Pauw
Published 2010-01-01

Involvement of membrane GRP78 in trophoblastic cell fusion.

by Sarah Fradet, Sandra Pierredon, Pascale Ribaux, Manuella Epiney, Kazuo Shin Ya, Olivier Irion, Marie Cohen
Published 2012-01-01

The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells.

by Nassima Temime-Smaali, Lionel Guittat, Assitan Sidibe, Kazuo Shin-ya, Chantal Trentesaux, Jean-François Riou
Published 2009-09-01

Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase

by Kei Kudo, Takehiro Nishimura, Ikuko Kozone, Junko Hashimoto, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Published 2021-05-01

In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives

by Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-ya
Published 2020-08-01

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

by Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe
Published 2018-08-01

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

by Takahiro Nakamura, Sachiko Okabe, Haruka Yoshida, Keisuke Iida, Yue Ma, Shogo Sasaki, Takao Yamori, Kazuo Shin-ya, Ichiro Nakano, Kazuo Nagasawa, Hiroyuki Seimiya
Published 2017-06-01

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host

by Keita Amagai, Haruo Ikeda, Junko Hashimoto, Ikuko Kozone, Miho Izumikawa, Fumitaka Kudo, Tadashi Eguchi, Takemichi Nakamura, Hiroyuki Osada, Shunji Takahashi, Kazuo Shin-ya
Published 2017-06-01

<i>C</i>-Methylation of <i>S</i>-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a...

by Chitose Maruyama, Yukiko Chinone, Shusuke Sato, Fumitaka Kudo, Kosuke Ohsawa, Junya Kubota, Junko Hashimoto, Ikuko Kozone, Takayuki Doi, Kazuo Shin-ya, Tadashi Eguchi, Yoshimitsu Hamano
Published 2020-05-01

MIDDAS-M: motif-independent de novo detection of secondary metabolite gene clusters through the integration of genome sequencing and transcriptome data.

by Myco Umemura, Hideaki Koike, Nozomi Nagano, Tomoko Ishii, Jin Kawano, Noriko Yamane, Ikuko Kozone, Katsuhisa Horimoto, Kazuo Shin-ya, Kiyoshi Asai, Jiujiang Yu, Joan W Bennett, Masayuki Machida
Published 2013-01-01

Novel Plant-Associated <i>Acidobacteria</i> Promotes Growth of Common Floating Aquatic Plants, Duckweeds

by Yasuko Yoneda, Kyosuke Yamamoto, Ayaka Makino, Yasuhiro Tanaka, Xian-Ying Meng, Junko Hashimoto, Kazuo Shin-ya, Noriyuki Satoh, Manabu Fujie, Tadashi Toyama, Kazuhiro Mori, Michihiko Ike, Masaaki Morikawa, Yoichi Kamagata, Hideyuki Tamaki
Published 2021-05-01

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

by Soniya Bastola, Marat S. Pavlyukov, Daisuke Yamashita, Sadashib Ghosh, Heejin Cho, Noritaka Kagaya, Zhuo Zhang, Mutsuko Minata, Yeri Lee, Hirokazu Sadahiro, Shinobu Yamaguchi, Svetlana Komarova, Eddy Yang, James Markert, Louis B. Nabors, Krishna Bhat, James Lee, Qin Chen, David K. Crossman, Kazuo Shin-Ya, Do-Hyun Nam, Ichiro Nakano
Published 2020-09-01