Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis

Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis

Summary: Background & Aims: Aramchol is a fatty acid-bile acid conjugate that reduces liver fat content and is being evaluated in a phase III clinical trial for non-alcoholic steatohepatitis (NASH). Aramchol attenuates NASH in mouse models and decreases steatosis by downregulating the fatty...

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Bibliographic Details
Main Authors: Dipankar Bhattacharya, Brittany Basta, Jose M. Mato, Amanda Craig, David Fernández-Ramos, Fernando Lopitz-Otsoa, Darya Tsvirkun, Liat Hayardeny, Vasuretha Chandar, Robert E. Schwartz, Augusto Villanueva, Scott L. Friedman
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:JHEP Reports
Subjects:
Fibrosis
Non-alcoholic steatohepatitis
Fatty liver disease
Hepatic fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921000136

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http://www.sciencedirect.com/science/article/pii/S2589555921000136

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