Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.

Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice.

Maintenance of normal mineral ion homeostasis is crucial for many biological activities, including proper mineralization of the skeleton. Parathyroid hormone (PTH), Klotho, and FGF23 have been shown to act as key regulators of serum calcium and phosphate homeostasis through a complex feedback mechan...

Full description

Bibliographic Details
Main Authors: Quan Yuan, Tadatoshi Sato, Michael Densmore, Hiroaki Saito, Christiane Schüler, Reinhold G Erben, Beate Lanske
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3355080?pdf=render

Internet

http://europepmc.org/articles/PMC3355080?pdf=render

Similar Items