A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis.

A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis.

BACKGROUND:Studies on the myotonic dystrophy protein kinase (DMPK) gene and gene products have thus far mainly concentrated on the fate of length mutation in the (CTG)n repeat at the DNA level and consequences of repeat expansion at the RNA level in DM1 patients and disease models. Surprisingly litt...

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Bibliographic Details
Main Authors: Ralph J A Oude Ophuis, Mietske Wijers, Miranda B Bennink, Fons A J van de Loo, Jack A M Fransen, Bé Wieringa, Derick G Wansink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2778554?pdf=render

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http://europepmc.org/articles/PMC2778554?pdf=render

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