In Vivo Evaluation of a New Recombinant Hyaluronidase to Improve Gene Electro-Transfer Protocols for DNA-Based Drug Delivery against Cancer

In Vivo Evaluation of a New Recombinant Hyaluronidase to Improve Gene Electro-Transfer Protocols for DNA-Based Drug Delivery against Cancer

Cancer vaccines based on plasmid DNA represent a good therapeutic perspective, despite their low potency. Animal-derived hyaluronidases (Hyals) are employed in oncological clinical practice. Hyal has been also demonstrated to be a good enhancer of intramuscular Gene Electro-Transfer (GET) efficiency...

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Bibliographic Details
Main Authors: Mariangela De Robertis, Lise Pasquet, Luisa Loiacono, Elisabeth Bellard, Luciano Messina, Susanna Vaccaro, Roberta Di Pasquale, Vito Michele Fazio, Marie-Pierre Rols, Justin Teissie, Muriel Golzio, Emanuela Signori
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
DNA-based drug delivery
hyaluronidase
gene electro-transfer
DNA vaccination
cancer therapy
oncoimmunology
translational protocols
Online Access:https://www.mdpi.com/2072-6694/10/11/405

Internet

https://www.mdpi.com/2072-6694/10/11/405

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