Detection of TET2, KRAS and CBL variants by Next Generation Sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML

Detection of TET2, KRAS and CBL variants by Next Generation Sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML

Background: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder in terms of cytogenetic and molecular aberrations. Ten-Eleven-Translocation 2 (TET2), Kirsten rat sarcoma viral oncogene homolog (KRAS), and Casitas B-cell lymphoma (CBL) have an important role pathogenesis of acute myeloid...

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Bibliographic Details
Main Authors: Dilara Fatma Akin, Deniz Aslar Oner, Mine Mumcuoglu, Ustun Ezer, Muhterem Bahce, Emin Kurekci, Nejat Akar
Format: Article
Language:English
Published: SpringerOpen 2016-04-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Childhood acute myeloid leukemia
Mutation
TET2
KRAS
CBL
Next Generation Sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S1110863015001123

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http://www.sciencedirect.com/science/article/pii/S1110863015001123

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