HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer

HER2 Heterogeneity Is Associated with Poor Survival in HER2-Positive Breast Cancer

Intratumoral human epidermal growth factor receptor 2 (HER2) heterogeneity has been reported in 16–36% of HER2-positive breast cancer and its clinical impact is under discussion. We examined the biological effects of HER2-heterogeneity on mouse models and analyzed metastatic brains by RNA...

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Bibliographic Details
Main Authors: Mari Hosonaga, Yoshimi Arima, Oltea Sampetrean, Daisuke Komura, Ikuko Koya, Takashi Sasaki, Eiichi Sato, Hideyuki Okano, Jun Kudoh, Shumpei Ishikawa, Hideyuki Saya, Takashi Ishikawa
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
HER2
heterogeneity
breast cancer
poor prognosis
caspase-1
Online Access:http://www.mdpi.com/1422-0067/19/8/2158

Internet

http://www.mdpi.com/1422-0067/19/8/2158

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