Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

Several anthrapyrazolone derivatives derived from 7-chloroanthra[1,9-cd]pyrazol-6(2H)-one and 7-chloro-2-(2-hydroxyethyl)anthra[1,9-cd] pyrazol-6(2H)-one have been prepared by the addition or substitution nucleophilic reactions and further transformed into extended tetracyclic systems and fused to d...

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Main Authors: Tsung-Chih Chen, Jih-Hwa Guh, Hui-Wen Hsu, Chun-Liang Chen, Chia-Chung Lee, Chia-Lun Wu, Yu-Ru Lee, Jing-Jer Lin, Dah-Shyong Yu, Hsu-Shan Huang
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535215001896