Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family

Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family

G protein-coupled receptors (GPCRs) can couple to more than one G protein subtype, and the coupling efficiency varies depending on the GPCR-G protein pair. Here authors use hydrogen/deuterium exchange mass spectrometry and mutagenesis to study the structural mechanism underlying primary and secondar...

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Bibliographic Details
Main Authors: Hee Ryung Kim, Jun Xu, Shoji Maeda, Nguyen Minh Duc, Donghoon Ahn, Yang Du, Ka Young Chung
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16975-2

Internet

https://doi.org/10.1038/s41467-020-16975-2

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