The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia

The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia

Abstract Background Ligand-driven modulation of the mitochondrial translocator protein 18 kDa (TSPO) was recently described to dampen the neuroinflammatory response of microglia in a retinal light damage model resulting in protective effects on photoreceptors. We characterized the effects of the TSP...

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Bibliographic Details
Main Authors: Kristin Mages, Felix Grassmann, Herbert Jägle, Rainer Rupprecht, Bernhard H. F. Weber, Stefanie M. Hauck, Antje Grosche
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Neuroinflammation
Subjects:
Retina
TSPO
Müller cell
Microglia
Gliosis
Ischemia
Online Access:http://link.springer.com/article/10.1186/s12974-019-1424-5

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http://link.springer.com/article/10.1186/s12974-019-1424-5

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