The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
Abstract Background Ligand-driven modulation of the mitochondrial translocator protein 18 kDa (TSPO) was recently described to dampen the neuroinflammatory response of microglia in a retinal light damage model resulting in protective effects on photoreceptors. We characterized the effects of the TSP...
Main Authors: | Kristin Mages, Felix Grassmann, Herbert Jägle, Rainer Rupprecht, Bernhard H. F. Weber, Stefanie M. Hauck, Antje Grosche |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-02-01
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Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12974-019-1424-5 |
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