Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

Neuronal programmed cell death (PCD) contributes to delayed tissue damage after traumatic brain injury (TBI). Both caspase-dependent and caspase-independent mechanisms have been implicated, with the latter including apoptosis inducing factor (AIF). The peptidyl-proplyl isomerase Cyclophilin A (CypA)...

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Bibliographic Details
Main Authors: Chun-Shu Piao, David J. Loane, Bogdan A. Stoica, Shihong Li, Marie Hanscom, Rainier Cabatbat, Klas Blomgren, Alan I. Faden
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Neurobiology of Disease
Subjects:
Traumatic brain injury
Apoptosis inducing factor
Caspase
Cyclophilin A
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000897

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http://www.sciencedirect.com/science/article/pii/S0969996112000897

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