Adjustment for index event bias in genome-wide association studies of subsequent events

Adjustment for index event bias in genome-wide association studies of subsequent events

Different from GWAS for susceptibility to disease, GWAS for prognosis or survival may be vulnerable to selection bias. Here, Dudbridge et al present an approach to reduce index event bias in simulated and realistic situations, and apply it to GWAS of survival with idiopathic pulmonary fibrosis and C...

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Bibliographic Details
Main Authors: Frank Dudbridge, Richard J. Allen, Nuala A. Sheehan, A. Floriaan Schmidt, James C. Lee, R. Gisli Jenkins, Louise V. Wain, Aroon D. Hingorani, Riyaz S. Patel
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09381-w

Internet

https://doi.org/10.1038/s41467-019-09381-w

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