6′-Hydroxy Justicidin B Triggers a Critical Imbalance in Ca2+ Homeostasis and Mitochondrion-Dependent Cell Death in Human Leukemia K562 Cells

6′-Hydroxy Justicidin B Triggers a Critical Imbalance in Ca2+ Homeostasis and Mitochondrion-Dependent Cell Death in Human Leukemia K562 Cells

Justicia procumbens (J. procumbens) is a traditional Chinese herbal medicine which was used for the treatment of fever, pain, and cancer. A compound 6′-hydroxy justicidin B (HJB) isolated from J. procumbens exhibits promising biological properties. However, the mechanism of action and the in vivo be...

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Bibliographic Details
Main Authors: Jiaoyang Luo, Jiaan Qin, Yanwei Fu, Shanshan Zhang, Xingguo Zhang, Meihua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
6′-hydroxy justicidin B
mitochondria
Ca2+ homeostasis
caspase
apoptosis
pharmacokinetics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00601/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00601/full

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