Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment.

BACKGROUND:The Kennedy pathway generates phosphocoline and phosphoethanolamine through its two branches. Choline Kinase (ChoK) is the first enzyme of the Kennedy branch of synthesis of phosphocholine, the major component of the plasma membrane. ChoK family of proteins is composed by ChoKalpha and Ch...

Full description

Bibliographic Details
Main Authors: David Gallego-Ortega, Ana Ramirez de Molina, Maria Angeles Ramos, Fatima Valdes-Mora, Maria Gonzalez Barderas, Jacinto Sarmentero-Estrada, Juan Carlos Lacal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2773002?pdf=render