Addition of hydrochlorothiazide to angiotensin receptor blocker therapy can achieve a lower sodium balance with no acceleration of intrarenal renin angiotensin system in patients with chronic kidney disease

Addition of hydrochlorothiazide to angiotensin receptor blocker therapy can achieve a lower sodium balance with no acceleration of intrarenal renin angiotensin system in patients with chronic kidney disease

Objective: Angiotensin receptor blockers (ARBs) produce a lower sodium (Na) balance, and the natriuretic effect is enhanced under Na deprivation, despite falls in blood pressure (BP) and glomerular filtration rate (GFR). Methods: The effect of additional hydrochlorothiazide (HCTZ; 12.5 mg/day) to AR...

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Bibliographic Details
Main Authors: Daisuke Fuwa, Michio Fukuda, Yoshiaki Ogiyama, Ryo Sato, Masashi Mizuno, Toshiyuki Miura, Sumiko Abe-Dohmae, Makoto Michikawa, Hiroyuki Kobori, Nobuyuki Ohte
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2016-06-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.1177/1470320316652032

Internet

https://doi.org/10.1177/1470320316652032

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