Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease

Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung disease

Pulmonary fibrosis is strongly associated with telomere shortening and increased DNA damage. Key cells in the pathogenesis involve alveolar type 2 (AT2) cells, club cells and myofibroblasts; however, to what extent these cells are affected by telomere shortening and DNA damage is not yet known. We s...

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Bibliographic Details
Main Authors: Aernoud A. van Batenburg, Karin M. Kazemier, Matthijs F.M. van Oosterhout, Joanne J. van der Vis, Jan C. Grutters, Roel Goldschmeding, Coline H.M. van Moorsel
Format: Article
Language:English
Published: European Respiratory Society 2021-05-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/7/2/00691-2020.full

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http://openres.ersjournals.com/content/7/2/00691-2020.full

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