Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies

Arginine-Depleting Enzymes – An Increasingly Recognized Treatment Strategy for Therapy-Refractory Malignancies

Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosis. Arginine auxotrophy however renders these tumors vulnerabl...

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Bibliographic Details
Main Authors: Christin Riess, Fatemeh Shokraie, Carl Friedrich Classen, Bernd Kreikemeyer, Tomas Fiedler, Christian Junghanss, Claudia Maletzki
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Combination therapy
Arginine-auxotrophy
Arginine deiminase
Therapy resistance
Tumor microenvironment
Online Access:https://www.karger.com/Article/FullText/495382

Internet

https://www.karger.com/Article/FullText/495382

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