LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State

LRP1 Modulates APP Intraneuronal Transport and Processing in Its Monomeric and Dimeric State

The low-density lipoprotein receptor-related protein 1, LRP1, interacts with APP and affects its processing. This is assumed to be mostly caused by the impact of LRP1 on APP endocytosis. More recently, also an interaction of APP and LRP1 early in the secretory pathway was reported whereat retention...

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Bibliographic Details
Main Authors: Claus U. Pietrzik, Stefan Kins, Uta-Mareike Herr, Paul Strecker, Steffen E. Storck, Carolin Thomas, Verena Rabiej, Anne Junker, Sandra Schilling, Nadine Schmidt, C. Marie Dowds, Simone Eggert
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
amyloid precursor protein (APP)
dimerization
transport
low density lipoprotein receptor-related protein 1 (LRP1)
processing
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00118/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00118/full

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