Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...

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Bibliographic Details
Main Authors: Kristoffer K. Hendel, Charlotte Bagger, Uffe H. Olesen, Christian Janfelt, Steen H. Hansen, Merete Haedersdal, Catharina M. Lerche
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
bleomycin
drug delivery
fractional laser
maldi-msi
skin cancer
Online Access:http://dx.doi.org/10.1080/10717544.2019.1574937

Internet

http://dx.doi.org/10.1080/10717544.2019.1574937

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