Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

Abstract Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow adhesion assay with TNF‐activated primary human microvascular endothelial cells, we demonstrate that IE isolated from Malawia...

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Bibliographic Details
Main Authors: Janet Storm, Jakob S Jespersen, Karl B Seydel, Tadge Szestak, Maurice Mbewe, Ngawina V Chisala, Patricia Phula, Christian W Wang, Terrie E Taylor, Christopher A Moxon, Thomas Lavstsen, Alister G Craig
Format: Article
Language:English
Published: Wiley 2019-02-01
Series:EMBO Molecular Medicine
Subjects:
cerebral malaria
cytoadherence
paediatric patient isolates
PfEMP1
Plasmodium falciparum
Online Access:https://doi.org/10.15252/emmm.201809164

Internet

https://doi.org/10.15252/emmm.201809164

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