Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63

Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63

Disseminated tumor cells often become dormant before awakening for metastatic growth. Here, the authors report that the lncRNA, NR2F1-AS1, is upregulated in dormant mesenchymal-like breast cancer stem-like cells and promotes dissemination but inhibits proliferation, leading to metastatic dormancy.

Bibliographic Details
Main Authors: Yingjie Liu, Peiyuan Zhang, Qiuyao Wu, Houqin Fang, Yuan Wang, Yansen Xiao, Min Cong, Tingting Wang, Yunfei He, Chengxin Ma, Pu Tian, Yajun Liang, Lun-Xiu Qin, Qingcheng Yang, Qifeng Yang, Lujian Liao, Guohong Hu
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25552-0

Internet

https://doi.org/10.1038/s41467-021-25552-0

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