Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S]

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S]

The use of nicotinic acid to treat dyslipidemia is limited by induction of a “flushing” response, mediated in part by the interaction of prostaglandin D2 (PGD2) with its G-protein coupled receptor, DP1 (Ptgdr). The impact of DP1 blockade (genetic or pharmacologic) was assessed in experimental murine...

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Bibliographic Details
Main Authors: Alison M. Strack, Ester Carballo-Jane, Sheng-ping Wang, Jiyan Xue, Xiaoli Ping, Lesley Ann McNamara, Anil Thankappan, Olga Price, Michael Wolff, T.J. Wu, Douglas Kawka, Michele Mariano, Charlotte Burton, Ching H. Chang, Jing Chen, John Menke, Silvi Luell, Emanuel I. Zycband, Xinchun Tong, Richard Raubertas, Carl P. Sparrow, Brian Hubbard, John Woods, Gary O'Neill, M. Gerard Waters, Ayesha Sitlani
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Journal of Lipid Research
Subjects:
dyslipidemia
DP1 antagonist
atherosclerosis model
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520417729

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http://www.sciencedirect.com/science/article/pii/S0022227520417729

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