MiR-133a Mimic Alleviates T1DM-Induced Systolic Dysfunction in Akita: An MRI-Based Study

MiR-133a Mimic Alleviates T1DM-Induced Systolic Dysfunction in Akita: An MRI-Based Study

Diabetic cardiomyopathy is a leading cause of heart failure. Developing a novel therapeutic strategy for diabetic cardiomyopathy and characterizing animal models used for diabetes mellitus (DM) are important. Insulin 2 mutant (Ins2+/-) Akita is a spontaneous, genetic, mouse model for T1DM, which is...

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Bibliographic Details
Main Authors: Shyam Sundar Nandi, Hamid Reza Shahshahan, Quanliang Shang, Shelby Kutty, Michael Boska, Paras Kumar Mishra
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
Ins2+/- Akita
miR-133a
cardiac dysfunction
MRI
fibrosis
hypertrophy
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01275/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01275/full

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