Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02582-1 |
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doaj-07ebcb03963546dcad91d3831f14ddd02021-05-11T10:07:18ZengNature Publishing GroupNature Communications2041-17232018-01-019111510.1038/s41467-017-02582-1Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNANina Rehage0Elena Davydova1Christine Conrad2Gesine Behrens3Andreas Maiser4Jenny E. Stehklein5Sven Brenner6Juliane Klein7Aicha Jeridi8Anne Hoffmann9Eunhae Lee10Umberto Dianzani11Rob Willemsen12Regina Feederle13Kristin Reiche14Jörg Hackermüller15Heinrich Leonhardt16Sonia Sharma17Dierk Niessing18Vigo Heissmeyer19Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenGroup Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum MünchenInstitute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenInstitute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenCenter for Integrated Protein Science at the Department of Biology, Ludwig-Maximilians-Universität MünchenResearch Unit Molecular Immune Regulation, Helmholtz Zentrum MünchenResearch Unit Molecular Immune Regulation, Helmholtz Zentrum MünchenInstitute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenResearch Unit Molecular Immune Regulation, Helmholtz Zentrum MünchenYoung Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research – UFZDivision of Cell Biology, La Jolla Institute for Allergy and ImmunologyDepartment of Health Sciences, Universita’ del Piemonte OrientaleCBG Department of Clinical Genetics, Erasmus MCMonoclonal Antibody Core Facility and Research Group, Institute for Diabetes and Obesity, Helmholtz Zentrum MünchenBioinformatic Unit, Department of Diagnostics, Fraunhofer Institute for Cell Therapy and Immunology- IZIYoung Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research – UFZCenter for Integrated Protein Science at the Department of Biology, Ludwig-Maximilians-Universität MünchenDivision of Cell Biology, La Jolla Institute for Allergy and ImmunologyGroup Intracellular Transport and RNA Biology, Institute of Structural Biology, Helmholtz Zentrum MünchenInstitute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenThe RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition.https://doi.org/10.1038/s41467-017-02582-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Nina Rehage Elena Davydova Christine Conrad Gesine Behrens Andreas Maiser Jenny E. Stehklein Sven Brenner Juliane Klein Aicha Jeridi Anne Hoffmann Eunhae Lee Umberto Dianzani Rob Willemsen Regina Feederle Kristin Reiche Jörg Hackermüller Heinrich Leonhardt Sonia Sharma Dierk Niessing Vigo Heissmeyer |
| spellingShingle |
Nina Rehage Elena Davydova Christine Conrad Gesine Behrens Andreas Maiser Jenny E. Stehklein Sven Brenner Juliane Klein Aicha Jeridi Anne Hoffmann Eunhae Lee Umberto Dianzani Rob Willemsen Regina Feederle Kristin Reiche Jörg Hackermüller Heinrich Leonhardt Sonia Sharma Dierk Niessing Vigo Heissmeyer Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA Nature Communications |
| author_facet |
Nina Rehage Elena Davydova Christine Conrad Gesine Behrens Andreas Maiser Jenny E. Stehklein Sven Brenner Juliane Klein Aicha Jeridi Anne Hoffmann Eunhae Lee Umberto Dianzani Rob Willemsen Regina Feederle Kristin Reiche Jörg Hackermüller Heinrich Leonhardt Sonia Sharma Dierk Niessing Vigo Heissmeyer |
| author_sort |
Nina Rehage |
| title |
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA |
| title_short |
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA |
| title_full |
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA |
| title_fullStr |
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA |
| title_full_unstemmed |
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA |
| title_sort |
binding of nufip2 to roquin promotes recognition and regulation of icos mrna |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-01-01 |
| description |
The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin mRNA target recognition. |
| url |
https://doi.org/10.1038/s41467-017-02582-1 |
| work_keys_str_mv |
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