Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis

Arthropod-borne rickettsial pathogens cause mild and severe human disease worldwide. The tick-borne pathogen Rickettsia parkeri elicits skin lesions (eschars) and disseminated disease in humans; however, inbred mice are generally resistant to infection. We report that intradermal infection of mice l...

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Bibliographic Details
Main Authors: Thomas P Burke, Patrik Engström, Cuong J Tran, Ingeborg M Langohr, Dustin R Glasner, Diego A Espinosa, Eva Harris, Matthew D Welch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
interferons
eschar-associated rickettsiosis
rickettsia
actin-based motility
type i interferon
immunity
Online Access:https://elifesciences.org/articles/67029

Internet

https://elifesciences.org/articles/67029

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