The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling.

The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling.

Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB), the synthetic analog of the mycobacterial cord factor trehalose-6,6-dimycolate (TDM), is a potent adjuvant inducing strong Th1 and Th17 immune responses. We pr...

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Bibliographic Details
Main Authors: Christiane Desel, Kerstin Werninghaus, Manuel Ritter, Katrin Jozefowski, Jens Wenzel, Norman Russkamp, Ulrike Schleicher, Dennis Christensen, Stefan Wirtz, Carsten Kirschning, Else Marie Agger, Clarissa Prazeres da Costa, Roland Lang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3538599?pdf=render

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http://europepmc.org/articles/PMC3538599?pdf=render

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