Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis

Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis

In previous studies of septal heart muscle from HCM patients with hypertrophic obstructive cardiomyopathy (HOCM, LVOT gradient 50–120 mmHg) we found that the level of phosphorylation of troponin I (TnI) and myosin binding protein C (MyBP-C) was extremely low yet samples from hearts with HCM or DCM m...

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Bibliographic Details
Main Authors: O’neal Copeland, Andrew Messer, Andrew Jabbour, Corrado Poggesi, Sanjay Prasad, Steven Marston
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Physiology
Subjects:
troponin I
phosphorylation
aortic stenosis
pressure overload
cardiomyopathy
protein kinase A
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00241/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00241/full

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